Regular Exercise throughout a person’s life can help them keep their brain active, and reduces the risks of neurological diseases like dementia, a new research study has found.
A study published online in the journal eLife found that a regular exercise routine can naturally build certain chemicals in brain, and initiates the production of BDNF called “Miracle-Gro for Brain”, for its role in growth of nerve cells and increased memory.
Moses Chao, professor at New York University in the US and his team said, “We believe that our study shows a precise biological mechanism behind increased BDNF production in mammals due to exercise.”
“Sorting out the mysteries of BDNF is significant as we search for more ways to physically keep mammalian brains healthy, including those of humans,” Chao added.
By sorting out the puzzling BDNF production to logically keep the mammalian brains healthy, researchers found that Ketone, a chemical produced in the liver called beta-hydroxybutyrate (DBHB) can trigger the biological reaction that stimulates the BDNF gene to generate more protein.
The beta-hydroxybutyrate that is produced in the body and brain via exercise were found to protect the other proteins in the brain called histone deacetylase complexes or HDACs from curbing BDNF build up by changing the atmosphere of BDNF gene.
The study team have compared the mice brains that are allowed to run at will on a cage wheel for 30 minutes to the brains of mice that did not run.
Chao added, “Our findings suggest how we might boost production of BDNF as studies have confirmed that doing so protects the brain.”
The study team have utilized the commercially available psychiatric drugs, which are known to relax the mood and protect seizures by inhibiting HDACs and awake the clogged BDNF gene, treating it effortlessly to cause the action and enhance the BDNF generation by 50 per cent.